Bayesian Graphical Regression.

ABSTRACT: We consider the problem of modeling conditional independence structures in heterogeneous data in the presence of additional subject-level covariates - termed Graphical Regression. We propose a novel specification of a conditional (in)dependence function of covariates - which allows the structure of a directed graph to vary flexibly with the covariates; imposes sparsity in both edge and covariate selection; produces both subject-specific and predictive graphs; and is computationally tractable. We provide theoretical justifications of our modeling endeavor, in terms of graphical model selection consistency. We demonstrate the performance of our method through rigorous simulation studies. We illustrate our approach in a cancer genomics-based precision medicine paradigm, where-in we explore ge

SUBMITTER: Ni Y 

PROVIDER: S-EPMC10021014 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature