Characterization of Oral Microbiota Following Chemotherapy in Patients With Hematopoietic Malignancies.

ABSTRACT: Oral microbiota may be associated with serious local or systemic medical conditions resulting from chemotherapy. This study was conducted to evaluate the changes in the oral microbiota following the initiation of chemotherapy in patients with hematopoietic malignancies and to identify the characteristics of the oral microbiota associated with oral mucositis. Oral samples were collected from 57 patients with hematopoietic malignancies at 2 time points: before the start of chemotherapy and 8 to 20 days after the start of chemotherapy, when chemotherapy-induced oral mucositis often occurs, and 16S rRNA metagenomic analyses were performed. Comparative and linear discriminant analysis effect size (LEfSe) analyses were used to determine the characteristic bacterial groups before and after the in

SUBMITTER: Omori M 

PROVIDER: S-EPMC10021090 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature