Plasmodium falciparum importation does not sustain malaria transmission in a semi-arid region of Kenya.

ABSTRACT: Human movement impacts the spread and transmission of infectious diseases. Recently, a large reservoir of Plasmodium falciparum malaria was identified in a semi-arid region of northwestern Kenya historically considered unsuitable for malaria transmission. Understanding the sources and patterns of transmission attributable to human movement would aid in designing and targeting interventions to decrease the unexpectedly high malaria burden in the region. Toward this goal, polymorphic parasite genes (ama1, csp) in residents and passengers traveling to Central Turkana were genotyped by amplicon deep sequencing. Genotyping and epidemiological data were combined to assess parasite importation. The contribution of travel to malaria transmission was estimated by modelling case reproductive numbers

SUBMITTER: Markwalter CF 

PROVIDER: S-EPMC10021402 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature