Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses.

ABSTRACT: TNF mediates a variety of biological processes including cellular proliferation, inflammatory responses, and cell death and is therefore associated with numerous pathologies including autoinflammatory diseases and septic shock. The inflammatory and cell death responses to TNF have been studied extensively downstream of TNF-R1 and are believed to rely on the formation of proinflammatory complex I and prodeath complex II, respectively. We recently identified a similar multimeric complex downstream of TLR4, termed the TRIFosome, that regulates inflammation and cell death in response to LPS or Yersinia pseudotuberculosis. We present evidence of a role for the TRIFosome downstream of TNF-R1, independent of TLR3 or TLR4 engagement. Specifically, TNF-induced cell death and inflammation in

SUBMITTER: Muendlein HI 

PROVIDER: S-EPMC10021564 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature