Immune response to co-administration of measles, mumps, and rubella (MMR), and yellow fever vaccines: a randomized non-inferiority trial among one-year-old children in Argentina.

ABSTRACT:

Background

In yellow fever (YF) endemic areas, measles, mumps, and rubella (MMR), and YF vaccines are often co-administered in childhood vaccination schedules. Because these are live vaccines, we assessed potential immune interference that could result from co-administration.

Methods

We conducted an open-label, randomized non-inferiority trial among healthy 1-year-olds in Misiones Province, Argentina. Children were randomized to one of three groups (1:1:1): Co-administration of MMR and YF vaccines (MMR₁YF₁), MMR followed by YF vaccine four weeks later (MMR₁YF₂), or YF followed by MMR vaccine four weeks later (YF₁MMR₂). Blood samples obtained pre-vaccination and 28 days post-vaccination were tested for immunogl

SUBMITTER: Vizzotti C 

PROVIDER: S-EPMC10021967 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature