Novel serum biomarkers for predicting neurological outcomes in postcardiac arrest patients treated with targeted temperature management.

ABSTRACT:

Objective

To determine the clinical feasibility of novel serum biomarkers in out-of-hospital cardiac arrest (OHCA) patients treated with target temperature management (TTM).

Methods

This study was a prospective observational study conducted on OHCA patients who underwent TTM. We measured conventional biomarkers, neuron‑specific enolase and S100 calcium-binding protein (S-100B), as well as novel biomarkers, including tau protein, neurofilament light chain (NFL), glial fibrillary acidic protein (GFAP), and ubiquitin C-terminal hydrolase-L1 (UCH-L1), at 0, 24, 48, and 72 h after the return of spontaneous circulation identified by SIMOA immunoassay. The primary outcome was poor neurological outcome at 6 months after OHCA.

Results

A total of 100 patients were included in t

SUBMITTER: Song H 

PROVIDER: S-EPMC10022069 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature