Relationships between circulating metabolites and facial skin aging: a Mendelian randomization study.

ABSTRACT:

Background

Blood metabolites are important to various aspects of our health. However, currently, there is little evidence about the role of circulating metabolites in the process of skin aging.

Objectives

To examine the potential effects of circulating metabolites on the process of skin aging.

Method

In the primary analyses, we applied several MR methods to study the associations between 249 metabolites and facial skin aging risk. In the secondary analyses, we replicated the analyses with another array of datasets including 123 metabolites. MR Bayesian model averaging (MR-BMA) method was further used to prioritize the metabolites for the identification of predominant metabolites that are associated with skin aging.

Results

In the primary analyses, only the unsa

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10022075 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature