Exploring preconception signatures of metabolites in mothers with gestational diabetes mellitus using a non-targeted approach.

ABSTRACT:

Background

Metabolomic changes during pregnancy have been suggested to underlie the etiology of gestational diabetes mellitus (GDM). However, research on metabolites during preconception is lacking. Therefore, this study aimed to investigate distinctive metabolites during the preconception phase between GDM and non-GDM controls in a nested case-control study in Singapore.

Methods

Within a Singapore preconception cohort, we included 33 Chinese pregnant women diagnosed with GDM according to the IADPSG criteria between 24 and 28 weeks of gestation. We then matched them with 33 non-GDM Chinese women by age and pre-pregnancy body mass index (ppBMI) within the same cohort. We performed a non-targeted metabolomics approach using fasting serum samples collected within 12 months prio

SUBMITTER: Li LJ 

PROVIDER: S-EPMC10022116 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature