The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults.

ABSTRACT:

Background

Insulin resistance (IR) and type 2 diabetes have been found to increase the risk for Alzheimer's clinical syndrome in epidemiologic studies but have not been associated with tau tangles in neuropathological research and have been inconsistently associated with cerebrospinal fluid P-tau181. IR and type 2 diabetes are well-recognized vascular risk factors. Some studies suggest that cardiovascular risk may act synergistically with cortical amyloid to increase tau measured using tau PET. Utilizing data from largely nondemented middle-aged and older adult cohorts enriched for AD risk, we investigated the association of IR and diabetes to tau PET and whether amyloid moderated those relationships.

Methods

Participants were enrolled in either the Wisconsin Registry for Al

SUBMITTER: Ennis GE 

PROVIDER: S-EPMC10022314 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature