Uric acid is independently associated with interleukin-1β levels in tear fluid of hyperuricemia and gout patients.

ABSTRACT:

Objectives

To explore pro-inflammatory cytokines status in the tear fluid of patients with hyperuricemia and gout and its association with uric acid level.

Methods

A total of 58 control subjects, 58 hyperuricemia patients including 40 asymptomatic hyperuricemia and 18 gout participants were recruited in this study. For tear analysis, each patient's tears were collected using capillary action microcaps after stimulation. Tear uric acid levels were measured using chemiluminescence. Tear and serum interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels were measured using enzyme-linked immunosorbent assay. The correlation of serum and tear uric acid levels with IL-1β and TNF-α were determined.

Results

Tear uric acid levels were significantly higher in hy

SUBMITTER: Wu M 

PROVIDER: S-EPMC10022423 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature