Dataset Information

Network Pharmacology Revealed the Mechanisms of Action of Lithospermum erythrorhizon Sieb on Atopic Dermatitis.

ABSTRACT:

Aim

The application of network analysis algorithms promoted the development of network pharmacology. This study aimed to combine network pharmacology and signed random walk with restart (SRWR) to reveal the mechanism by which Lithospermum erythrorhizon Sieb (LES) exerts effects on atopic dermatitis (AD).

Methods

The compounds and targets of LES were retrieved from Traditional Chinese Medicine Integrated Database (TCMID) and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and important compounds and targets were identified by intersection analysis and protein-protein interaction (PPI) network.

Results

We found that active LES-derived compounds such as caffeic acid, Isovaleric acid, Arnebinol, and Alannan may inhibit PTGS2, HSP90AA1 and MAPK14, which are key mediators involved in PI3K-Akt pathway, vascular endothelial growth factor signaling pathway, Fc epsilon RI signaling pathway, and calcium signaling pathway.

Conclusion

The application of SRWR could identify potential targets of LES with a low false-positive rate and help elucidate the mechanism of action of traditional Chinese medicine.

SUBMITTER: Wang T

PROVIDER: S-EPMC10022454 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Network Pharmacology Revealed the Mechanisms of Action of <i>Lithospermum erythrorhizon</i> Sieb on Atopic Dermatitis.

Wang Tianyi T You Wang W Zhao Linna L Zhang Bingxin B Wang Hongmei H

Clinical, cosmetic and investigational dermatology 20230313

<h4>Aim</h4>The application of network analysis algorithms promoted the development of network pharmacology. This study aimed to combine network pharmacology and signed random walk with restart (SRWR) to reveal the mechanism by which <i>Lithospermum erythrorhizon</i> Sieb (LES) exerts effects on atopic dermatitis (AD).<h4>Methods</h4>The compounds and targets of LES were retrieved from Traditional Chinese Medicine Integrated Database (TCMID) and Traditional Chinese Medicine Systems Pharmacology ...[more]

PMID: 36936755

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