Maternal androgens and autism spectrum disorder in the MARBLES prospective cohort study.

ABSTRACT:

Background

Maternal hormonal risk factors for autism spectrum disorder (ASD) in offspring could intersect genetic and environmental risk factors.

Objectives

This analysis explored ASD risk in association with maternal testosterone, androstenedione, and dehydroepiandrosterone (DHEA) measured in first, second, and third trimesters of pregnancy.

Methods

MARBLES is a prospective pregnancy cohort study based at the MIND Institute in Northern California that enrolls mothers who have at least one child previously diagnosed with ASD and are expecting, or planning to have another child. At 36 months the younger sibling is clinically classified as having ASD, or as non-typically developing (Non-TD), or typically developing (TD). Maternal androgens during pregnancy were measured

SUBMITTER: Granillo L 

PROVIDER: S-EPMC10022653 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature