Continued Posttrial Benefits of Buprenorphine Extended Release: RECOVER Study Findings.

ABSTRACT:

Background

This analysis describes participants' opioid use disorder (OUD) outcomes for 18 months after discontinuing extended-release buprenorphine injection (BUP-XR, SUBLOCADE).

Methods

The RECOVER (Remission From Chronic Opioid Use: Studying Environmental and Socioeconomic Factors on Recovery) study recruited participants from BUP-XR clinical trials (NCT02357901, NCT025100142, and NCT02896296) to assess whether there were sustained benefits after leaving the trial. Abstinence from opioids and from all illicit substances (excluding medical cannabis), health-related quality of life, depression, and employment were measured after BUP-XR discontinuation and change in outcomes assessed at 6, 12, and 18 months. Results were analyzed within the full cohort and by duration of BUP

SUBMITTER: Boyett B 

PROVIDER: S-EPMC10022675 | biostudies-literature | 2023 Mar-Apr 01

REPOSITORIES: biostudies-literature