Placental Inflammation Leads to Abnormal Embryonic Heart Development.

ABSTRACT:

Background

Placental heart development and embryonic heart development occur in parallel, and these organs have been proposed to exert reciprocal regulation during gestation. Poor placentation has been associated with congenital heart disease, an important cause of infant mortality. However, the mechanisms by which altered placental development can lead to congenital heart disease remain unresolved.

Methods

In this study, we use an in vivo neutrophil-driven placental inflammation model through antibody depletion of maternal circulating neutrophils at key stages during time-mated murine pregnancy: embryonic days 4.5 and 7.5. Pregnant mice were culled at embryonic day 14.5 to assess placental and embryonic heart development. A combination of flow cytometry, histology, and bulk

SUBMITTER: Ward EJ 

PROVIDER: S-EPMC10022676 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature