Field model for multistate lateral diffusion of various transmembrane proteins observed in living Dictyostelium cells.

ABSTRACT: The lateral diffusion of transmembrane proteins on plasma membranes is a fundamental process for various cellular functions. Diffusion properties specific for individual protein species have been extensively studied, but the common features among protein species are poorly understood. Here, we systematically studied the lateral diffusion of various transmembrane proteins in the lower eukaryote Dictyostelium discoideum cells using a hidden Markov model for single-molecule trajectories obtained experimentally. As common features, all membrane proteins that had from one to ten transmembrane regions adopted three free diffusion states with similar diffusion coefficients regardless of their structural variability. All protein species reduced their mobility similarly upon the inhibition of micro

SUBMITTER: Takebayashi K 

PROVIDER: S-EPMC10022678 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature