The C-terminus of the cargo receptor Erv14 affects COPII vesicle formation and cargo delivery.

ABSTRACT: The endoplasmic reticulum (ER) is the start site of the secretory pathway, where newly synthesized secreted and membrane proteins are packaged into COPII vesicles through direct interaction with the COPII coat or aided by specific cargo receptors. Little is known about how post-translational modification events regulate packaging of cargo into COPII vesicles. The Saccharomyces cerevisiae protein Erv14, also known as cornichon, belongs to a conserved family of cargo receptors required for the selection and ER export of transmembrane proteins. In this work, we show the importance of a phosphorylation consensus site (S134) at the C-terminus of Erv14. Mimicking phosphorylation of S134 (S134D) prevents the incorporation of Erv14 into COPII vesicles, delays cell growth, exacerbates growth of sec

SUBMITTER: Lagunas-Gomez D 

PROVIDER: S-EPMC10022740 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature