Development, refinement, and characterization of a nonhuman primate critical care environment.

ABSTRACT:

Background

Systemic inflammatory response remains a poorly understood cause of morbidity and mortality after traumatic injury. Recent nonhuman primate (NHP) trauma models have been used to characterize the systemic response to trauma, but none have incorporated a critical care phase without the use of general anesthesia. We describe the development of a prolonged critical care environment with sedation and ventilation support, and also report corresponding NHP biologic and inflammatory markers.

Methods

Eight adult male rhesus macaques underwent ventilation with sedation for 48-96 hours in a critical care setting. Three of these NHPs underwent "sham" procedures as part of trauma control model development. Blood counts, chemistries, coagulation studies, and cytokines/chemokine

SUBMITTER: Bozzay JD 

PROVIDER: S-EPMC10022766 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature