Crohn's Disease Is Associated with Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease.

ABSTRACT:

Background

Chronic inflammation in IBD is postulated to drive NAFLD progression from steatosis to fibrosis.

Aims

To study the histopathological spectrum of NAFLD in Crohn disease (CD) and Ulcerative colitis (UC).

Methods

Patients with biopsy proven NAFLD at a quaternary center from 2008 to 2018 were included in this retrospective analysis. Inflammatory bowel disease (IBD) diagnosed either clinically and/or endoscopically at the time of liver biopsy. Multivariable regression and propensity score (PS) weighted analysis were conducted. Statistical analysis were performed using SAS statistical software.

Results

Among 1009 patients with NAFLD a diagnosis of IBD was identified in 50 cases (34 CD and 16 UC). On multivariable analysis; CD was independently associated w

SUBMITTER: Aggarwal M 

PROVIDER: S-EPMC10022843 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature