Development and Validation of a Genomic Profile for the Omission of Local Adjuvant Radiation in Breast Cancer.

ABSTRACT:

Purpose

Adjuvant radiotherapy (RT) is used for women with early-stage invasive breast cancer treated with breast-conserving surgery. However, some women with low risk of recurrence may safely be spared RT. This study aimed to identify these women using a molecular-based approach.

Methods

We analyzed two randomized trials of women with node-negative invasive breast cancer to ± RT following breast-conserving surgery: SweBCG91-RT (stage I-II, no adjuvant systemic therapy) and Princess Margaret (age 50 years or older, T1-T2, adjuvant tamoxifen). Transcriptome-wide profiling was performed (Affymetrix Human Exon 1.0 ST microarray). Patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative tumors and with gene expression data were included. The SweB

SUBMITTER: Sjostrom M 

PROVIDER: S-EPMC10022846 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature