Rapid neutrophil mobilization by VCAM-1+ endothelial cell-derived extracellular vesicles.

ABSTRACT:

Aims

Acute myocardial infarction rapidly increases blood neutrophils (<2 h). Release from bone marrow, in response to chemokine elevation, has been considered their source, but chemokine levels peak up to 24 h after injury, and after neutrophil elevation. This suggests that additional non-chemokine-dependent processes may be involved. Endothelial cell (EC) activation promotes the rapid (<30 min) release of extracellular vesicles (EVs), which have emerged as an important means of cell-cell signalling and are thus a potential mechanism for communicating with remote tissues.

Methods and results

Here, we show that injury to the myocardium rapidly mobilizes neutrophils from the spleen to peripheral blood and induces their transcriptional activation prior to arrival at the injured

SUBMITTER: Akbar N 

PROVIDER: S-EPMC10022859 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature