Properties and fate of human mesenchymal stem cells upon miRNA let-7f-promoted recruitment to atherosclerotic plaques.

ABSTRACT:

Aims

Atherosclerosis is a chronic inflammatory disease of the arteries leading to the formation of atheromatous plaques. Human mesenchymal stem cells (hMSCs) are recruited from the circulation into plaques where in response to their environment they adopt a phenotype with immunomodulatory properties. However, the mechanisms underlying hMSC function in these processes are unclear. Recently, we described that miRNA let-7f controls hMSC invasion guided by inflammatory cytokines and chemokines. Here, we investigated the role of let-7f in hMSC tropism to human atheromas and the effects of the plaque microenvironment on cell fate and release of soluble factors.

Methods and results

Incubation of hMSCs with LL-37, an antimicrobial peptide abundantly found in plaques, increased biosy

SUBMITTER: Egea V 

PROVIDER: S-EPMC10022860 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature