Eosinophils protect pressure overload- and β-adrenoreceptor agonist-induced cardiac hypertrophy.

ABSTRACT:

Aims

Blood eosinophil (EOS) counts and EOS cationic protein (ECP) levels associate positively with major cardiovascular disease (CVD) risk factors and prevalence. This study investigates the role of EOS in cardiac hypertrophy.

Methods and results

A retrospective cross-section study of 644 consecutive inpatients with hypertension examined the association between blood EOS counts and cardiac hypertrophy. Pressure overload- and β-adrenoreceptor agonist isoproterenol-induced cardiac hypertrophy was produced in EOS-deficient ΔdblGATA mice. This study revealed positive correlations between blood EOS counts and left ventricular (LV) mass and mass index in humans. ΔdblGATA mice showed exacerbated cardiac hypertrophy and dysfunction, with increased LV wall thickness, reduced LV inter

SUBMITTER: Yang C 

PROVIDER: S-EPMC10022866 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature