Characterization of regional differences in resting-state fMRI with a data-driven network model of brain dynamics.

ABSTRACT: Model-based data analysis of whole-brain dynamics links the observed data to model parameters in a network of neural masses. Recently, studies focused on the role of regional variance of model parameters. Such analyses however necessarily depend on the properties of preselected neural mass model. We introduce a method to infer from the functional data both the neural mass model representing the regional dynamics and the region- and subject-specific parameters while respecting the known network structure. We apply the method to human resting-state fMRI. We find that the underlying dynamics can be described as noisy fluctuations around a single fixed point. The method reliably discovers three regional parameters with clear and distinct role in the dynamics, one of which is strongly correlate

SUBMITTER: Sip V 

PROVIDER: S-EPMC10022900 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature