Analysis of endometrial carcinoma TCGA reveals differences in DNA methylation in tumors from Black and White women.

ABSTRACT:

Objective

Racial disparities exist in cancer patients both in incidence and death rates. In endometrial cancer, Black patients are reported to have higher incidence of aggressive endometrial cancer subtypes and higher death rates than White women. To date, diagnostic and prognostic biomarkers associated with race-specific methylation driven genes have yet to be identified. The objective of this study was to explore DNA methylation patterns in endometrial tumor samples from White and Black women.

Methods

Differentially methylated CpGs (DMCs) and differentially methylated regions (DMRs) were identified in White tumor samples compared to Black tumor samples using Endometrial Carcinoma (EC) methylation and clinical data from The Cancer Genome Atlas (TCGA). Survival analysis was

SUBMITTER: Asif H 

PROVIDER: S-EPMC10023328 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature