Uncomplicated Streptococcal Bacteremia: The Era of Oral Antibiotic Step-down Therapy?

ABSTRACT:

Background

The purpose of this study was to compare the clinical outcomes of adults with uncomplicated streptococcal bacteremia who received either oral (PO) step-down or continued intravenous (IV) therapy.

Methods

This was a retrospective, single-center, cohort study, including adults admitted with Streptococcal bloodstream infection between January 1, 2013, and December 31, 2020. Only patients with uncomplicated Streptococcal bloodstream infections were included. Patients who transitioned to PO therapy within 5 days from bacteremia onset were compared to patients receiving continued IV therapy. The primary outcome was clinical failure, defined by either 90-day hospital readmission or mortality. Secondary outcomes included hospital length of stay (LOS) and antibiotic-relate

SUBMITTER: Waked R 

PROVIDER: S-EPMC10023366 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature