MELD-Lactate Predicts Poor Outcome in Variceal Bleeding in Cirrhosis.

ABSTRACT:

Background

Predictors of poor outcome associated with variceal bleeding remain suboptimal. In patients with cirrhosis, serum lactate combined with Model for End-Stage Liver Disease (MELD-LA) improved prediction across heterogeneous populations. However, prognostic properties have not yet been assessed in the context of variceal bleeding.

Aims

We aimed to evaluate the predictive performance of MELD-LA compared to MELD, lactate, and nadir hemoglobin in cirrhosis patients with variceal bleeding.

Methods

In this multicenter study, we identified 472 patients with variceal bleeding from a German primary cohort (University Hospitals Hamburg/Frankfurt/Cologne), and two independent external validation cohorts [Veterans Affairs (VA), Baylor University]. Discrimination for 30-da

SUBMITTER: Horvatits T 

PROVIDER: S-EPMC10023372 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature