Genetic variants associated with post-traumatic stress symptoms in patients with gynecologic cancer.

ABSTRACT:

Objective

Patients with cancer experience symptoms of post-traumatic stress disorder (PTSD) more commonly than the general population. The objective of this study was to identify single nucleotide polymorphisms (SNPs) associated with increased risk of post-traumatic stress disorder (PTSD) in patients with gynecologic cancer.

Methods

A prospective cohort study recruited 181 gynecologic cancer survivors receiving care at the University of Minnesota between 2017 and 2020 who completed PTSD DSM-V surveys to self-report their symptoms of PTSD and provided saliva samples. DNA samples were genotyped for 11 SNPs in 9 genes involved in dopaminergic, serotonergic, and opioidergic systems previously associated with risk of PTSD in populations without cancer.

Results

Most partici

SUBMITTER: Johnson AM 

PROVIDER: S-EPMC10023401 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature