Dopamine replacement therapy normalizes reactive step length to postural perturbations in Parkinson's disease.

ABSTRACT:

Background

Postural instability is one of the most disabling motor symptoms of Parkinson's disease (PD) given its association with falls and loss of independence. Previous studies have assessed biomechanical measures of reactive stepping in response to perturbations, showing that individuals with PD exhibit inadequate postural responses to regain balance.

Research question

Does dopamine replacement therapy normalize step length in response to balance perturbations?

Methods

In this study, we estimated reactive step length, to a postural perturbation, retrospectively from a dataset of frontal plane video using 2D motion tracking and direct linear transform methods. We compared two perturbation methods: support surface translation and shoulder pull (the clinical standard

SUBMITTER: Herbers C 

PROVIDER: S-EPMC10023411 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature