CircFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p.

ABSTRACT:

Background

Intra-abdominal infections are the second most common cause of sepsis in the intensive care unit. Intestinal epithelial injury due to abdominal sepsis results in a variety of pathological changes, such as intestinal bacteria and toxins entering the blood, leading to persistent systemic inflammation and multiple organ dysfunction. The increased apoptosis of intestinal epithelial cells induced by sepsis further exacerbates the progression of sepsis. Although several studies have revealed that circRNAs are involved in intestinal epithelial injury in sepsis, few studies have identified the roles of circRNAs in intestinal epithelial apoptosis.

Methods

We used laser capture microdissection to obtain purified epithelial cells located in intestinal crypts from four patien

SUBMITTER: Ye L 

PROVIDER: S-EPMC10023616 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature