Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb.

ABSTRACT: The development and survival of adult-born neurons are believed to be driven by sensory signaling. Here, in vivo analyses of motility, morphology and Ca²⁺ signaling, as well as transcriptome analyses of adult-born juxtaglomerular cells with reduced endogenous excitability (via cell-specific overexpression of either Kv1.2 or Kir2.1 K⁺ channels), revealed a pronounced impairment of migration, morphogenesis, survival, and functional integration of these cells into the mouse olfactory bulb, accompanied by a reduction in cytosolic Ca²⁺ fluctuations, phosphorylation of CREB and pCREB-mediated gene expression. Moreover, K⁺ channel overexpression strongly downregulated genes involved in neuronal migration, differentiation, and morphogenesis and upregulat

SUBMITTER: Li K 

PROVIDER: S-EPMC10023654 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature