Antipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia.

ABSTRACT: Recent postmortem transcriptomic studies of schizophrenia (SCZ) have shown hundreds of differentially expressed genes. However, the extent to which these gene expression changes reflect antipsychotic drug (APD) exposure remains uncertain. We compared differential gene expression in the prefrontal cortex of SCZ patients who tested positive for APDs at the time of death with SCZ patients who did not. APD exposure was associated with numerous changes in the brain transcriptome, especially among SCZ patients on atypical APDs. Brain transcriptome data from macaques chronically treated with APDs showed that APDs affect the expression of many functionally relevant genes, some of which show expression changes in the same directions as those observed in SCZ. Co-expression modules enriched for synap

SUBMITTER: Schulmann A 

PROVIDER: S-EPMC10023659 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature