Dynamic nomogram for predicting generalized conversion in adult-onset ocular myasthenia gravis.

ABSTRACT:

Purpose

To explore the factors and risk mapping model of progression from ocular myasthenia gravis (OMG) to generalized myasthenia gravis (GMG) in adult-onset patients.

Methods

A retrospective, observational cohort study was performed for 435 OMG patients with onset age older than 14 years old. Multivariate Cox regression was used to identify the independent factors affecting generalized conversions that then were incorporated into the construction of the nomogram.

Results

Two hundred thirty-seven patients (54.5%) had transformed into GMG after a median of 1.1 years (range 0.1--9.1 years). The 6-, 12-, and 24-month generalized conversion rates were 31.7%, 49.8%, and 65.4%, respectively. Multivariable analysis showed that the early-onset age, male sex, concomitant auto

SUBMITTER: Bi Z 

PROVIDER: S-EPMC10023757 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature