Systematic analysis of prophage elements in actinobacterial genomes reveals a remarkable phylogenetic diversity.

ABSTRACT: Actinobacteria represent one of the largest bacterial phyla harboring many species of high medical, biotechnological and ecological relevance. Prophage elements are major contributors to bacterial genome diversity and were shown to significantly shape bacterial fitness and host-microbe interactions. In this study, we performed a systematic analysis of prophage elements in 2406 complete actinobacterial genomes. Overall, 2106 prophage elements were predicted to be present in about 50% (1172/2406) of the analyzed datasets. Interestingly, these identified sequences compose a high prevalence of cryptic prophage elements, indicating genetic decay and domestication. Analysis of the sequence relationship of predicted prophages with known actinobacteriophage genomes revealed an exceptional high phy

SUBMITTER: Sharma V 

PROVIDER: S-EPMC10023795 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature