Kinin B₁ and B₂ receptors mediate cancer pain associated with both the tumor and oncology therapy using aromatase inhibitors.

ABSTRACT: Pain caused by the tumor or aromatase inhibitors (AIs) is a disabling symptom in breast cancer survivors. Their mechanisms are unclear, but pro-algesic and inflammatory mediators seem to be involved. Kinins are endogenous algogenic mediators associated with various painful conditions via B₁ and B₂ receptor activation, including chemotherapy-induced pain and breast cancer proliferation. We investigate the involvement of the kinin B₁ and B₂ receptors in metastatic breast tumor (4T1 breast cancer cells)-caused pain and in aromatase inhibitors (anastrozole or letrozole) therapy-associated pain. A protocol associating the tumor and antineoplastic therapy was also performed. Kinin receptors' role was investigated via pharmacological antagonism, recepto

SUBMITTER: Brusco I 

PROVIDER: S-EPMC10023805 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature