Structuring supramolecular hyaluronan hydrogels via peptide self-assembly for modulating the cell microenvironment.

ABSTRACT: The use of synthetic extracellular matrices (ECMs) in fundamental in vitro cell culture studies has been instrumental for investigating the interplay between cells and matrix components. To provide cells with a more native environment in vitro, it is desirable to design matrices that are biomimetic and emulate compositional and structural features of natural ECMs. Here, the supramolecular fabrication of peptide-hyaluronan (HA) hydrogels is presented as potential ECM surrogates, combining native HA and rationally designed cationic amphipatic peptides [(KI)_nK, lysine (K), isoleucine (I), n ​= ​2-6] whose mechanical properties and microstructure are tunable by the peptide sequence. (KI)_nK peptides adopt β-sheet configuration and self-assemble into filamento

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC10024175 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature