The complex genetic architecture of Alzheimer's disease: novel insights and future directions.

ABSTRACT:

Background

Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. AD is highly heritable, with heritability estimates of ∼70% from twin studies. Progressively larger genome-wide association studies (GWAS) have continued to expand our knowledge of AD/dementia genetic architecture. Until recently these efforts had identified 39 disease susceptibility loci in European ancestry populations.

Recent developments

Two new AD/dementia GWAS have dramatically expanded the sample sizes and the number of disease susceptibility loci. The first increased total sample size to 1,126,563-with an effective sample size of 332,376-by predominantly including new biobank and population-based dementia datasets. The second, expands on an

SUBMITTER: Andrews SJ 

PROVIDER: S-EPMC10024184 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature