Spatiotemporal expression patterns of genes coding for plasmalemmal chloride transporters and channels in neurological diseases.

ABSTRACT: Neuronal voltage changes which are dependent on chloride transporters and channels are involved in forming neural functions during early development and maintaining their stability until adulthood. The intracellular chloride concentration maintains a steady state, which is delicately regulated by various genes coding for chloride transporters and channels (GClTC) on the plasmalemma; however, the synergistic effect of these genes in central nervous system disorders remains unclear. In this study, we first defined 10 gene clusters with similar temporal expression patterns, and identified 41 GClTC related to brain developmental process. Then, we found 4 clusters containing 22 GClTC were enriched for the neuronal functions. The GClTC from different clusters presented distinct cell type prefere

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10024392 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature