Molecular and spatial signatures of mouse brain aging at single-cell resolution.

ABSTRACT: The diversity and complex organization of cells in the brain have hindered systematic characterization of age-related changes in its cellular and molecular architecture, limiting our ability to understand the mechanisms underlying its functional decline during aging. Here, we generated a high-resolution cell atlas of brain aging within the frontal cortex and striatum using spatially resolved single-cell transcriptomics and quantified changes in gene expression and spatial organization of major cell types in these regions over the mouse lifespan. We observed substantially more pronounced changes in cell state, gene expression, and spatial organization of non-neuronal cells over neurons. Our data revealed molecular and spatial signatures of glial and immune cell activation during aging, part

SUBMITTER: Allen WE 

PROVIDER: S-EPMC10024607 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature