An updated systematic review of HIV-associated cryptococcal meningitis treatment strategies.

ABSTRACT:

Background

The purpose of this systematic review is to provide updated evidence on the preferred induction therapy for the treatment of HIV-associated cryptococcal meningitis considering the most recent evidence available in order to inform the need for updates to WHO guidelines.

Methods

We searched Medline via PubMed, EMBASE, the Cochrane Library and clinicaltrials.gov for published or completed randomized clinical trials that evaluated induction treatment of first episode HIV-associated cryptococcal meningitis from 9 July 2018 (date of last search) to 1 September 2021.

Results

One randomized clinical trial of 844 people with HIV-associated cryptococcal meningitis met the inclusion criteria. Participants were randomized to: (1) amphotericin deoxycholate for 7 days, w

SUBMITTER: Shapiro AE 

PROVIDER: S-EPMC10024640 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature