The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis.

ABSTRACT: The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished the efficacy of almost all available antibiotics, complicating efforts to combat the spread of this global health burden. Alongside the development of new drugs, optimised drug combinations are needed to improve treatment success and prevent the further spread of antibiotic resistance. Typically, antibiotic resistance leads to reduced sensitivity, yet in some cases the evolution of drug resistance can lead to enhanced sensitivity to unrelated drugs. This phenomenon of collateral sensitivity is largely unexplored in M. tuberculosis but has the potential to identify alternative therapeutic strategies to combat drug-resistant strains that are unresponsive to current treatments. Here, by using drug suscept

SUBMITTER: Waller NJE 

PROVIDER: S-EPMC10024696 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature