MR-guided ultrasound-stimulated microbubble therapy enhances radiation-induced tumor response

ABSTRACT: High intensity focused ultrasound (HIFU) systems have been approved for therapeutic ultrasound delivery to cause tissue ablation or induced hyperthermia. Microbubble agents have also been used in combination with sonication exposures. These require temperature feedback and monitoring to prevent unstable cavitation and prevent excess tissue heating. Previous work has utilized lower power and pressure to oscillate microbubbles and transfer energy to endothelial cells in the absence of thermally induced damage that can radiosensitize tumors. This work investigated whether reduced acoustic power and pressure on a commercial available MR-integrated HIFU system could result in enhanced radiation-induced tumor response after exposure to ultrasound-stimulated microbubbles (USMB) therapy. A commerc

SUBMITTER: McNabb E 

PROVIDER: S-EPMC10024768 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature