Particulate matter₁₀-induced airway inflammation and fibrosis can be regulated by chitinase-1 suppression.

ABSTRACT:

Background

Particulate matter₁₀ (PM₁₀) can induce airway inflammation and fibrosis. Recently, chitinase-1 has been shown to play key roles in inflammation and fibrosis. We aimed to investigate the effects of chitinase-1 inhibitor in PM₁₀-treated murine mice models.

Methods

In female BALB/c mice, PM₁₀ was intranasally administered six times over 3 weeks, and ovalbumin (OVA) was intraperitoneally injected and then intranasally administered. Chitinase-1 inhibitor (CPX) 6 times over 3 weeks or dexamethasone 3 times in the last week were intraperitoneally administered. Two days after the last challenges, mice were euthanized. Messenger RNA sequencing using lung homogenates was conducted to evaluate signaling pathways.

Results

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SUBMITTER: Choi YJ 

PROVIDER: S-EPMC10024831 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature