Exosomal MFI2-AS1 sponge miR-107 promotes non-small cell lung cancer progression through NFAT5.

ABSTRACT:

Background

Non-small cell lung cancer is a heterogeneous disease driven by extensive molecular alterations. Exosomes are small vesicles with diameters ranging from 30 to 150 nm released by various cell types and are important mediators of information transmission in tumor cells. Exosomes contain proteins, lipids, and various types of nucleic acids, including miRNAs and even DNA and RNA. MFI2 Antisense RNA 1 (MFI2-AS1) is a long noncoding RNA known to promote cell proliferation, metastasis and invasion in a variety of malignancies.

Methods

The relative expression of MFI2-AS1 in NSCLC tissues was examined using RNA fluorescence in situ hybridization (FISH) staining. Transwell migration and wound healing assays were used to analyze cell migration and invasion abilities. Tube fo

SUBMITTER: Xu J 

PROVIDER: S-EPMC10024841 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature