Macrophage-specific autophagy-related gene HSPB8 is involved in the macrophage polarization in atherosclerosis.

ABSTRACT:

Background

Atherosclerosis (AS) is a chronic inflammatory disease, as a main cause leading to vascular diseases worldwide. Although increasing studies have focused on macrophages in AS, the exact relating mechanism is still largely unclear. Our study aimed to explore the pathogenic role and diagnostic role of macrophage autophagy related genes (MARGs) in AS.

Methods

All datasets were downloaded from Gene Expression Omnibus database and Human Autophagy Database. The differential expression analysis and cross analysis were performed to identify candidate MARGs. GO and KEGG enrichment analyses were conducted to obtain the functional information. Moreover, we analyzed the correlation between target gene and macrophage polarization in AS. The correlation between target gene and p

SUBMITTER: Wang J 

PROVIDER: S-EPMC10024845 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature