U-shaped relationship between apolipoprotein A1 levels and mortality risk in men and women.

ABSTRACT:

Background

Apolipoprotein A1 (ApoA1) is the principal protein component of high-density lipoprotein (HDL). Although low HDL cholesterol (HDL-C) levels are known to be associated with greater cardiovascular risk, recent studies have also shown heightened mortality risk at very high HDL-C levels.

Aims

To investigate the sex-specific association between elevated ApoA1 levels and adverse outcomes, and their genetic basis.

Methods

A prospective cohort study of United Kingdom Biobank participants without coronary artery disease at enrollment was performed. The primary exposure was serum ApoA1 levels. The primary and secondary outcome measures were cardiovascular and all-cause death, respectively.

Results

In 402 783 participants followed for a median of 12.1 years, th

SUBMITTER: Faaborg-Andersen CC 

PROVIDER: S-EPMC10024919 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature