Primary ovarian insufficiency has strong familiality: results of a multigenerational genealogical study.

ABSTRACT:

Objective

To determine the familiality of primary ovarian insufficiency (POI) at population level through examination of multigenerational genealogical information linked to electronic medical records.

Design

Case-control study.

Setting

Not applicable.

Patient(s)

Women with POI were identified using International Classification of Disease 9 and 10 codes in electronic medical records (1995-2021) from 2 major health care systems in Utah and reviewed for accuracy. Cases were linked to genealogy information in the Utah Population Database (UPDB). All included POI cases (n = 396) were required to have genealogy information available for at least 3 generations of ancestors. The risk of POI in relatives was compared with population rates for POI matched by age, sex, a

SUBMITTER: Verrilli L 

PROVIDER: S-EPMC10024920 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature