Transcriptomic landscapes of effective and failed liver regeneration in humans.

ABSTRACT:

Background & aims

Although extensive experimental evidence on the process of liver regeneration exists, in humans, validation is largely missing. However, liver regeneration is critically affected by underlying liver disease. Within this project, we aimed to systematically assess early transcriptional changes during liver regeneration in humans and further assess how these processes differ in people with dysfunctional liver regeneration.

Methods

Blood samples of 154 patients and intraoperative tissue samples of 46 patients undergoing liver resection were collected and classified with regard to dysfunctional postoperative liver regeneration. Of those, a matched cohort of 21 patients were used for RNA sequencing. Samples were assessed for circulating cytokines, gene expression

SUBMITTER: Starlinger P 

PROVIDER: S-EPMC10025111 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature