Penalized estimation of frailty-based illness-death models for semi-competing risks.

ABSTRACT: Semi-competing risks refer to the time-to-event analysis setting, where the occurrence of a non-terminal event is subject to whether a terminal event has occurred, but not vice versa. Semi-competing risks arise in a broad range of clinical contexts, including studies of preeclampsia, a condition that may arise during pregnancy and for which delivery is a terminal event. Models that acknowledge semi-competing risks enable investigation of relationships between covariates and the joint timing of the outcomes, but methods for model selection and prediction of semi-competing risks in high dimensions are lacking. Moreover, in such settings researchers commonly analyze only a single or composite outcome, losing valuable information and limiting clinical utility-in the obstetric setting, this mea

SUBMITTER: Reeder HT 

PROVIDER: S-EPMC10025166 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature