Clinical and epidemiological correlates of treatment change in patients with NMOSD: insights from the CIRCLES cohort.

ABSTRACT:

Objective

Neuromyelitis optica spectrum disorders (NMOSD) represent rare autoimmune diseases of the central nervous system largely targeting optic nerve(s) and spinal cord. The present analysis used real-world data to identify clinical and epidemiological correlates of treatment change in patients with NMOSD.

Methods

CIRCLES is a longitudinal, observational study of NMOSD conducted at 15 centers across North America. Patients with ≥ 60 days of follow-up and receiving on-study maintenance treatment were evaluated. The mean annual relapse rate (ARR) was estimated using negative binomial models; the likelihood of treatment change was estimated using Cox proportional hazards models. Relapses were included as time-varying covariates to estimate the relationship to treatment chang

SUBMITTER: Gholizadeh S 

PROVIDER: S-EPMC10025181 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature