Neurofilament light (NfL) as biomarker in serum and CSF in status epilepticus.

ABSTRACT:

Objective

We explored the potential of neurofilament light chain (NfL) in serum and cerebrospinal fluid as a biomarker for neurodestruction in status epilepticus.

Methods

In a retrospective analysis, we measured NfL in serum and cerebrospinal fluid samples of patients with status epilepticus using a highly sensitive single-molecule array technique (Simoa). Status epilepticus was diagnosed according to ILAE criteria. Additionally, we employed an alternative classification with more emphasis on the course of status epilepticus. We used data from three large control groups to compare NfL in status epilepticus versus neurologically healthy controls.

Results

We included 28 patients (mean age: 69.4 years, SD: 15 years) with a median status duration of 44 h (IQR: 80 h). Twen

SUBMITTER: Margraf NG 

PROVIDER: S-EPMC10025237 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature